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According to the IASP (International Association for the Study of Pain). Pain´s defined as an “unpleasant sensory or emotional experience associated with actual or potential damage to a tissue. Or described in terms of such damage”. Worldwide, pain is one of the most frequent causes of medical consultation.
has a great influence on the quality of life and the general functioning
Moreover, has a great influence on the quality of life and the general functioning of the patient. It is a subjunctive symptom since each patient feels it of a different intensity having its own threshold of pain. This threshold depends both on the sensory part that indicates that something in the body´s altered. Also, on the biological-somatic part where the psychic dimension and personal interpretation influence. It´s classified, according to its duration in time, in acute and chronic.
So, what is chronic pain?
Chronic pain’s characterized by lasting more than 3-6 months, may persist even if the cause has disappeared and can be sub classified into nociceptive pain (caused by inflamed or damaged tissue that activates the nociceptors of an intact nervous system) and neuropathic pain (caused by an injury or dysfunction of the nervous system).
Due to the high prevalence of pain and the difficult analgesic control of certain types of pain (for example, chronic and neuropathic pain). One of the fundamental objectives of pharmacological research is the search for new analgesic drugs. That have advantages over already existing. The discovery of the endocannabinoid system and its revelation as a central and peripheral neuromodulation system have called attention to its therapeutic potential as pain modulators especially in diseases such as cancer, multiple sclerosis, fibromyalgia, among others.
How can CBD help?
The analgesic properties of CBD are due to the presence of CB1 receptors (and in a smaller amount CB2, and TRPV). At the level of the central and peripheral nervous system. A pain stimulus comes through the nerve pathways to the spinal cord and from there it´s transmitted to areas of the brain related to the processing of pain. CBD causes the activation of cannabinoid receptors present in both the medulla and the brain that inhibit the transmission of these painful signals. At the peripheral level, in addition to inhibiting the transmission of signals. The activation of CB2 reduces the release of proinflammatory mediators at the site of the lesion.
How does the endocannabinoid system help?
The endocannabinoid system is frequently located together with the most powerful and best-known pain control system: the opioid system. Both are present in the main structures involved in the transmission of pain. It has been possible to observe a synergistic effect between both systems in the control of pain.
Based on this data we can conclude that the joint administration of CBD with opioids could enhance the analgesic effect. Offering also safety advantages since in this way the necessary amount of opioids reduces. Consequently the appearance of secondary effects due to them.
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Some of the benefits are:
# Slow reliese of CBD
# Lasts for 24 hours