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Let’s look at how CBD can help for Neurodegenerative Diseases.
During 70s, 80s, 90s the main lines of research focused on the use of cannabis to relieve temporarily the symptoms of some diseases. Such as nausea associated with chemotherapy, the lines of research are now focused on Search for the ability of cannabinoids to treat neurodegenerative diseases, such as multiple sclerosis, Alzheimer’s, Parkinson’s, Huntington’s, cerebral ischemia and amyotrophic lateral sclerosis.
Neurodegenerative diseases are chronic disorders characterized by the gradual loss of neurons in some areas of the central nervous system, in specific regions of the brain. Nowadays there´s not cure. Pharmacological treatments are currently limited to symptomatic therapies that don´t stop its evolution. Investigations with animal suggest that cannabinoids could reduce inflammation through the glial process, related to neuronal survival and protection of neurons at risk.
How can CBD help?
The actions of cannabinoids are complex and different on the receptors (CB1 and CB2), some act on other neurotransmission pathways. However, it is possible to assert that all these mechanisms tend to promote and restore balance. As well as to preserve the health of the noble elements of the nervous system. Moreover, to control those that may be responsible for the generation of a potential or ongoing damage.
THC and CBD are partial agonists of CB1 and 2 receptors, although with different potency, delta-9-THC being the most potent. CBD has low affinity for CB1 and 2 receptors. It is a powerful CB1 antagonist and inverse agonist of CB2. The inhibition of the transmission between neurons is the general action of cannabinoids. When they inhibit a neuron that stimulates will result in a relaxation of the muscle. Moreover, when they inhibit an inhibitory neuron, it will result in the stimulation of the game function. This therapeutic potential of cannabinoids is because of their ability to act on different cells of the CNS. Neurons, atrocities, microglia, oligodendrocytes and peri-vascular cells. Therefore, they can control their functions in degenerative, protective or repair processes.
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