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Despite many years of intensive research, pancreatic cancer remains the fourth leading cause of death. From cancer in the United States and fifth in the Western world in general. Approved current therapies based on the administration of chemoradiation with fluorouracil for locally advanced tumors and chemotherapy with gemcitabine for metastatic disease have only slightly increased the median survival of affected patients.
It had showed that cannabinoids, such as CBD, induce apoptosis of pancreatic tumor cell lines in vitro and exert a remarkable growth inhibitory effect in pancreatic cancer models in vivo. The latter effect is evident under several experimental scenarios (cells inoculated in different sites and cannabinoids administered by different routes). In addition, the results also show that cannabinoids exert a strong inhibitory effect. On the spread of pancreatic tumor cells not only to adjacent sites. Such as the spleen, but also to distal tissues, such as liver, diaphragm, stomach and intestine. Suggesting that these agents can also decrease the spread of pancreatic tumor cells.
How can CBD help?
Although the biopsies of the pancreatic tumors and cell lines analysed expressed cannabinoid receptors CB1 and CB. The findings indicate that the CB2 receptor is the one that plays a major role in the proapoptotic effect of cannabinoids in these cells. Previous observations had shown that the CB2 receptor is involved in the antitumor effect of cannabinoids on gliomas, skin carcinomas, lymphomas and prostate carcinomas, which may be clinically relevant since the selective activation of CB2 is not relating to the psychoactive effects typical of cannabis. However, the molecular mechanisms involved in these actions mediated by CB2 only partially understand.
The results, together with the data obtained in rat glioma and human astrocytoma cells. Show that regulation of p8 and ATF-4 mediates cannabinoid-induced apoptosis by induction of the proapoptotic protein TRB3. Of interest, it had recently showed that ATF-4 regulates the expression of TRB3. To induce apoptosis of transformed human cells. Is triggering this pathway by endoplasmic reticulum stress, and the results support that it also implicate in cannabinoid-induced apoptosis of human pancreatic tumor cells in vitro and in vivo.
Of potential interest for future cannabinoid-based therapies, treatment with cannabinoids does not appear to activate this pathway in the pancreas or spleen in the normal state, suggesting that these agents can activate the proapoptotic pathway of endoplasmic reticulum stress selectively in tumor cells.
In conclusion, the results presented here show that cannabinoids exert a remarkable antitumor effect on pancreatic cancer cells in vitro and in vivo due to their ability to selectively induce apoptosis of these cells by activating the proapoptotic p8-ATF pathway -4-TRB3. These findings can help establish the basis of a new therapeutic approach for the treatment of this deadly disease.
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Some of the benefits are:
# Helps with the symptoms of chemo
# Causes cancerous cells to go through apoptosis