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It is a very serious type of epilepsy whose causes are not known exactly yet.
Epilepsy is a brain disorder that causes repeated epileptic seizures in the patient over a period. These crises cause episodes of abnormal and uncontrolled activity in the neurons that modify the behaviour or attention of the patient. Because it manifests itself in many ways depending on the patient. Epilepsy had divided into different groups of syndromes in order to treat it better. One of which is the Lennox-Gastaut syndrome (LGS).
It is a very serious type of epilepsy whose causes are not known exactly yet. It appears in childhood, usually between 2 and 6 years of age, although its symptoms may occur eventually. In addition, it is an uncommon disorder, since it only affects 4% of patients with epilepsy, more frequently in men. However, in most cases, the disease worsens with the passage of time.
The symptoms of Lennox-Gastaut syndrome characterized by the appearance of recurrent and varied epileptic seizures. The slowing down of brain electrical activity, intellectual disability, memory and learning problems, motor alterations, spasms or violent muscular convulsions.
Those affected by Lennox-Gastaut syndrome are very difficult to treat, because not all medications are completely effective. In this disorder, there is usually some resistance to pharmacological treatment with anticonvulsants. This type of medication, in addition, can produce unwanted side effects.
How can CBD help?
Until now, the cannabinoid that has attracted the most attention is cannabidiol (CBD). Since it is not psychoactive and considered a safe molecule because it does not provide negative side effects compared to conventional anticonvulsant drugs. For what has been studied, the endocannabinoid system has an important function in the regulation of neuronal activity. Therefore, a malfunctioning of this could play a large role in the development of epilepsies. CBD has affinity with the CB1 and CB2 receptors of the system and, therefore, it can treat this area as well as provide other benefits.
Other studies more focused on Lennox-Gastaut syndrome also highlight the properties of cannabidiol to treat it. In recent years, there have been several investigations that emphasize CBD‘s ability to reduce epileptic seizures caused by the disease. Thus, the results are promising, as they suggest that CBD is safe and that patients with this type of epilepsy tolerate it better than usual antiepileptic drugs.
Although until now it can only be said that CBD is the cannabinoid that has the most properties to treat Lennox-Gastaut syndrome, it is believed that if other cannabinoids worked with it, the entourage effect could be achieved. It considered that, when this synergy occurs, stronger and more effective anticonvulsive effects can be achieved. However, there are still studies that can definitely confirm it.
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